Load the Unico package and | Deconvolution on pseudobulk RNA expression data | Cell-type level differential methylation analysis | Perform association testing under no distribution assumption | Calibration of asymptotically-derived p-values under null
Package: Unico 0.1.0
Zeyuan Chen
Unico: Unified Cross-Omics Deconvolution
UNIfied Cross-Omics deconvolution (Unico) deconvolves standard 2-dimensional bulk matrices of samples by features into a 3-dimensional tensors representing samples by features by cell types. Unico stands out as the first principled model-based deconvolution method that is theoretically justified for any heterogeneous genomic data. For more details see Chen and Rahmani et al. (2024) <doi:10.1101/2024.01.27.577588>.
Authors:
Unico_0.1.0.tar.gz
Unico_0.1.0.zip(r-4.7)Unico_0.1.0.zip(r-4.6)Unico_0.1.0.zip(r-4.5)
Unico_0.1.0.tgz(r-4.6-any)Unico_0.1.0.tgz(r-4.5-any)
Unico_0.1.0.tar.gz(r-4.7-any)Unico_0.1.0.tar.gz(r-4.6-any)
Unico_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
Unico/json (API)
| # Install 'Unico' in R: |
| install.packages('Unico', repos = c('https://cozygene.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/cozygene/unico/issues
Pkgdown/docs site:https://cozygene.github.io
Last updated from:5d44ded4f6. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 179 | ||
| source / vignettes | OK | 204 | ||
| linux-release-x86_64 | OK | 166 | ||
| macos-release-arm64 | OK | 155 | ||
| macos-oldrel-arm64 | OK | 176 | ||
| windows-devel | OK | 122 | ||
| windows-release | OK | 97 | ||
| windows-oldrel | OK | 94 | ||
| wasm-release | OK | 116 |
Exports:association_asymptoticassociation_parametricsimulate_datatensorUnico
Dependencies:bayesmcompositionsconfigdata.tableDEoptimRformatRfutile.loggerfutile.optionslambda.rlatticeMASSMatrixmatrixcalcmatrixStatsmgcvnlmenloptrpbapplypracmaRcppRcppArmadillorobustbasetensorAtestityaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Performs asymptotic statistical testing under no distribution assumption | association_asymptotic |
| Performs parametric statistical testing | association_parametric |
| Simulate data under Unico model assumption | simulate_data |
| Inferring the underlying source-specific 3D tensor | tensor |
| Fitting the Unico model | Unico |
